DCAF13-MEDIATED K63-LINKED UBIQUITINATION OF RNA POLYMERASE I PROMOTES UNCONTROLLED PROLIFERATION IN BREAST CANCER

DCAF13-mediated K63-linked ubiquitination of RNA polymerase I promotes uncontrolled proliferation in Breast Cancer

Abstract Hyperactivation of ribosome biogenesis (RiBi) drives cancer progression, yet the role of RiBi-associated proteins (RiBPs) in breast cancer (BC) is underexplored.In this study, we perform a comprehensive multi-omics analysis and reveal that assembly and maturation factors (AMFs), a subclass of RiBPs, are upregulated at both RNA and protein

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Spatial layout optimization model integrating layered attention mechanism in the development of smart tourism management

Tourism demand projection is paramount for both corporate operations and destination management, facilitating tourists in crafting bespoke, multifaceted itineraries and enriching their vacation experiences.This study proposes a multi-layer self attention mechanism recommendation algorithm based on dynamic spatial perception, with the aim of refinin

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